KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function
نویسندگان
چکیده
منابع مشابه
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Chromatin remodeling is fundamental for B-cell differentiation. In the present study, we explored the role of KAP1, the cofactor of KRAB-ZFP transcriptional repressors, in this process. B-lymphoid-specific Kap1-KO mice displayed reduced numbers of mature B cells, lower steady-state levels of Abs, and accelerated rates of decay of neutralizing Abs after viral immunization. Transcriptome analyses...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-12-401117